promoting factor (vitamine A). He stated that tests were already available, though less certainly quantitative in their indications, for the anti-rachitic vitamine, the water-soluble, growth-promoting vitamine (B), and the anti-scorbutic vitamine.
A discussion ensued, in the course of which it was suggested by the President that this Conference was hardly suitable in its constitution for discussing the whole question of the biological standard of vitamines. It appeared to him that such a discussion could more suitably be undertaken by a special Conference, analogous to the Serological Conference, attended by those workers in the different countries who were recognised experts in this specialist branch of enquiry. With regard to the proposed biological assay of cod-liver oil for vitamine A, he thought that this Conference might usefully promote investigation, in connection with a colour reaction recently described by Drs. Rosenheim and Drummond, of London, which was believed by these authors to be specific for vitamine A, and to be suitable for application as a quantitative, colorimetric test. If that belief could be substantiated by definite evidence, it was obvious that a simple chemical method would be preferable to a difficult and tedious biological one. He suggested that Professor Poulsson might possibly be able to obtain a series of samples of cod-liver oil, exhibiting widely different degrees of growth-promoting activity, and undertook to endeavour to arrange for a comparative investigation of these by chemical and biological tests in London, and, with Dr. Voegtlin's co-operation, possibly in the United States of America as well.
This suggestion met with general approval, and the Conference unanimously adopted the following resolutions :
"i That, in the opinion of this Conference, it is of great importance that the preparations used in therapeutics to supply vitamines to the patient should be standardised as accurately as possible, each for its content of its characteristic vitamine or vitamines.
"2. That the preparation for which such standardisation appears at present to be most important and most practicable is cod-liver oil, vitamine A (growth-promoting factor) being the constituent of this oil which can be most accurately assayed.
"3. That the general question of the accuracy and usefulness of methods for the standardisation of all vitamines could be more suitably considered by a special conference of experts, appointed for the purpose.
"4. That this Conference should limit its present activity to the initiation of a comparative test, designed to determine the accuracy and specificity of the colour-reaction for vitamin A, recently described by Drummond and Rosenheim.
"5. That, for the purpose of this investigation, the Conference invite Professor Poulsson, Professor Voegtlin and Dr. Dale to act as a Sub-Committee."
FIFTH MEETING, HELD ON SEPTEMBER 2ND, AT 3 P.M.
Dr. Rajchman attended the meeting and explained the desire of the Health Committee to have the opinion of the Conference with regard to the proposals which had been submitted to it for action in connection with the international control of the traffic in secret and proprietary remedies.
After general discussion, the Conference passed the following resolution :
"That the members of this Conference, representing expert pharmacological opinion from many countries, recognise and welcome the efforts made in different countries to control the traffic in secret remedies and in a certain kind of proprietary remedies, the existence of which they regard as detrimental/and as a menace to public health. They express the hope that the Health Committee'Sf the League of Nations will be able to find means to co-ordinate and centralise such efforts, so as to render them international ' in their effect and provide a basis on which the different countries may be able to deal with this matter, in the interest of the health of their own peoples." The Conference then considered and adopted the reports presented by its various Sub-Committees.
SIXTH MEETING, HELD ON SEPTEMBER 3RD, AT 10 A.M.
The Conference reviewed the resolutions adopted during the previous sessions and finally confirmed them, with certain modifications of verbal detail, which have been included in the resolutions, as presented in the Minutes of the earlier sessions.
On the suggestion of the Chairman, it was decided to send a message of greeting, on behalf of the Conference, to Professor J. J. Abel, of Baltimore, who had been a member of the first Conference at Edinburgh but was unable to be present on this occasion.
The Conference then discussed the question of outstanding problems, other than those considered in its previous sessions, on which investigations might usefully be promoted and co-ordinated. It was decided to recommend investigations on methods for the biological standardisation of para-thyroid extract and ovarian extract. The question of methods for biological measurement of other vitamines than vitamine A was again raised, and the opinion recorded that such work could most usefully be undertaken by a conference of specialists