5, 6 and 7 p.m. (5). To interpret correctly the curve for this day, 1
a Brief description of extracts (3) and (5) is necessary. The pan- I
creas from which these extracts were made was not completely degenerated.
The pancreatic ducts of the animal had iheen tied six weeks. Extract (£)
was made from the processus uncinatus- Extract (5) was made from the
remainder of the gland. The extract from the uncinate process was muck
weaker than the latter. In the four hours following the first injection
of sugar we recovered 9.94 grams in the urine* In the corresponding
period on the following day after the injection tff sugar plus extract
4.49 grams were recovered. Had we used the more powerful extract first'rf.
the reducing action might have been even more strikingly demonstrated.T ^
•J^^^^0"^Q were surprised that we did not secure a raised blood sugazUt/^
one hour after the first injection of sugar- The rise after the secdnd
injection was very marked. We gave the animal one day's rest and re4
peated the consecutive injections with the same results as a'bove. Tlie
interpretation of the results of the first of the latter injections i<s
complicated Jby an -u-nexplainably high percentage of sugar present befcfre
infection. This phenomenon can^iiot be wholly explained by the rsite
of output of sugar since on the fourth injectibs^ the first hour ex-;
cretion was the maximun of the series and we did obtain a definite rise
in blood sugaf. An injection of 1 gram of sugar per pctij^ give)i to a;
normal dog showed a pronounced rise in percentage stig3,r_pf^.>!ie blood
after a 15*minute interval. This hyperglycemia rapidly subsided and
at the end of an hour the blood sugar had regained its normal level.
t.^f
grams of sugar were excreted. Gomo light iua,y "U^"tufamwn on
irhe liidi
U)
Hemoglobin estimations v/ere made, one hour after the first
A
sugar injection. (2) just before the first injection of extract