Chart 'ill o m 1 .contains the record of a 6.5 kilogram dog (410)
This experiment is not conclusive hut is interesting to us at least,
since we administered the first dose of extract of degenerated pancreas
to this animal. On July
i
, the pancreas, with the exception of thef
J A^I.
processus uncinatus. was removed. ThsB process/was allowed to remain I
until July 18#i*, In the interval between the operations there was no f
hyperglycemia or glucosuria. The curves on subsequent days show the j
I
effect produced by the removal of the pedicle. It will be noted that I
as the experiment progresses the percentage blood sugar did not rise |
to the level usually attained in completely depancreatized animals , |
and also that there was a marked decrease in the daily amounts of |
nitrogen and sugar excreted and the volume of urine voided* The |
animal continued to lose weight and seemed to be entering the cachexia|
condition characteristic of depancreatized animals which had become
infected*.
, The chart for July 27£fcf shows the effect produced on/per-
centage /blcod sugar and/sugar excretion by the oral administration of |
twenty-five grains of dextrose in two hundred and fifty cc. of water. f
At 10 a.m. July 30£ff, the percentage/blood sugar was^.20. |
Four c,c. of extract of degenerated pancreas were injected intravenous!^
At 11 a.m. the blood sugar had fallen top.l2M^. The injections of }
extract are shown in the chart. At 12 a.m. twenty grams of sugar in
two hundred c,c. of water were given by stomach tube. The chart records!
the effect.|
^ The obvious criticism of this experiment is that the animal
v/as mc^ibWdPrrhe interesting features, which gave us great encourage-
ment are (l) the extract caused^a sudden fall in the blood sugar and
cL
(E) that in the presence of the extract the animal excrete^ .21 grams v^