\
effect of whole gland extract upon the amounts of sugar, urea and
acetone bodies in the blood and urine of diabetic animals. He states
that injections into peripheral veins produce no effect and his
experiments show that second injections do not produce such marked
effect as the first.
From the work of the above-mentioned observers we may conclude:|
(1) that the secretion produced by the acinous cells of the pancreas!
I
are in no way connected with carbohydrate utilization; (2) that all j
injections of whole-gland extract have been futile as a therapeutic j
measure in defects of carbohydrate utilization^ Mnp. wr . f\t\ till i j'nnfil
Qehll a1*4«s£3=Sft- Lu Iflt" Pdtub•^fea^^aanaraaiLij^ juice 4c -the mae-fe^
•tog-.&gen'b in frho baAff. .-BPlis third (3} POHQluaiaii io that the
islands of Langerhans are essential in the control of carbohydrate
metabolism. According to Macleod there are two possible mechanisms
by which the islets might accomplish this control:! (1) the blood
might be modified while passing through the islet tissue, i.e., the
islands might be detoxicating stations and (2) the islets might pro-
duce an internal secretion.
We submit the following experiments which we believe give con-
vincing evidence that it is this latter mechanism which is in operation
In the ten'week interval which we considered necessary for complete
degeneration of the acinous tissue, we secured records of dogs de- I
panereat ized by the Ee&jfn Method/\/r
Methods
The first chart is a record of an animal depancreatized by/Hed^n
method. The details of this operation gyre given in Hed^nfs articl
The remaining records are of animals /^completely depancreatized at the
^<5
initial operation. The procedure ytf^ as follows; f under general