*
operation. The fact was thus established that the pancreas was re- !
sponsible for this form of diabetes. In 1884, Arnozan% VaillarcK^Jf
had ligated the pancreatic ducts in rabbits and found that within
twenty-four hours the ducts become dilated; the epithelial cells
begin to desquamate; and that there are protoplasmic changes in the :
acinous cells. On the seventh day there is a beginning of round- :l
celled infiltration- On the fourteenth day the parenchyma was mostly
j
replaced by fibrous tissue- Sscobolewv^ in 190E noted in addition
to the above, that there.was a gradual atrophy and sclerosis of the]
pancreas with no glucosuria. However, in the later stages, from thirty
to one hundred and twenty days after ligation of the ducts, he found
involvement^ of the islets and accompanying glucosuria.\
LewaschewvXDelieved that the islets were modified acinous cells.
16 ix""'--TV""-"' • - "• -- •— .
Laguesse v; an anatomist, first suggested that the islets might be fthe
organ of pancreatic internal secretion. He showed that there were j
comparatively more islets in the fetus and the new-born than in the;
adult animal. Dpi e A/and SscobolewA/"independently furnished the
first clinical foundation for the belief that the islets were involved
in ^Pancreatic diabetes.I
) W. G. MacCallum"^, in 1909, ligated the ducts draining the tall
third of the pancreas* After seven months he excised the remaining!
two-thirds* This was followed by a mild glucosuria< Three weeks later
he removed the degenerated tail third. This second operation resulted
in an extreme and fatal glucosuria. Kirkbridge\r , in 1912, repeated
and corroborated MacCallumfs findings and, by the use of Lane's^v^;
method of staining, proved that the atrophic tissue contained healthy
islfets.