198 SCIENTIFIC PROCEEDINGS (127)
0.3 gram of thyroid extract every second day, the activity was
maintained above that of the normal sheep but no sudden and
pronounced increase was observed.
97 (2057)
Influence on the respiratory metabolian of pancreatic extract
administered by mouth to depancreatized dogs.
By C. B. F. CGIBBS and JOHN R. MURLIN.
[Prom the Physiological Laboratory of the University of Roches-
ter, Rochester, N. Y.]
Extracts of beef pancreas prepared in the same manner' as
extracts of dog's pancreas were prepared by Murlin and Kramer2
in 1913-6 and administered by mouth to depancreatized dogs
with glucose and NaOH in sufficient quantity to make the en-
tire mixture N/20 NaOH produced in all of four trials distinct
elevations of the respiratory quotients taken from two to four
hours afterward. In two of the four trials the extract was coin-
centrated and purified before administration and in both in-
stances the rise in quotient was greater than when crude un-
concentrated extract was given.
One of the experiments on a depancreatized dog is repro-
duced below.
Dog No. 40. Operated Nov. 28th, 1922.
Date. Time. 002 02 RQ
Dee. 1 12:40-1:35 2.943 4.271 0.689
1:35-2:47 4.073 6.151 0.662
2:47-3:48 3.330 4.799 0.694
Dec. 2 11:05-11:43 1.960 2.596 0.755
11:43-12:13 1.578 1.959 0.721
12:13-12:46 1.619 2.508
3:40 P.M. Dog given 50 c.c cone. No. 87(2) extract in
300 c.c water + 20 gm. glucose + N/20
NaOH (final reaction).
4:53-5:23 1.497 2.854 0.757
5:23-6:23 2.932 3.813 0.769
6:23-7:41 3.966 4.479 0.885
7:41-8:42 3.284 3.424 0.959
i Murlin, Kramer and Sweet, Journ. Metabolic Research, 1922, ii, 19.
2 Murlin and Rramer, Journ. of Biol. Chem., 1916, xxvii, 516.