HYALINE CASTS IN DOGS. 59
A similar difference was observed also in nephrectomized dogs.
It is claimed by some investigators that the glycemia following
depancreatization is due to an over-production of sugar. It is
evident that the hyperglycemia in our cases of depancreatization
can not be due to such a factor. We shall not discuss here whether
our results can be adequately explained by the assumption that
the removal of the pancreas causes a decrease of consumption
of dextrose by the body tissues. We wish, however, to indicate
that some of our facts hint at the possibility of a change in the
permeability of the endothelia of the circulatory apparatus as a
factor in the results of depancreatization.
The influence of the intra-intestinal administration of magnesium
sulphate on the production of hyaline casts in dogs.
By F. L. GATES.
[From the Department of Physiology and Pharmacology of the Rocke-
feller Institute for Medical Research.]
Following our study of hyaline cast production after the intra-
muscular or intravenous injection of hydrated magnesium sulphate
and certain other salts, reported to this society in February and
June of this year,' Dr. Meltzer suggested that the investigation be
carried further by a series of experiments in which the MgSO4
was given directly into the intestines, simulating its use as a
The typical procedure in the present series was to inject an m/I
solution of hydrated MgSO4, in doses of .I8 or .2 gm. per kilo.
body weight, through a glass cannula into the upper duodenum.
The small intestine was isolated by ligatures just below the
pylorus and at the ileo-cecal valve. The operation was per-
formed under complete ether anesthesia and the dogs were killed
at the end of five or six hours. For two animals the solution was
diluted to m/3 before injection and in three other cases the ligature
was not placed at the ileo-cecal valve. In each case control urines
were examined for casts and albumin.
PROC. SOC. EXP. BIOL. AND MED., Vol. XI, No. 3 (879); Vol. XI, No. 6 (9I9).