INFLUENCE OF PANCREATIC AND DUODENAL EXTRACTS. I73
the reduced elimination of that substance is proved by the following
experiment on another dog place in the respiration calorimeter.
DoG "S." OPERATED May 6.
D a t ~ e. i~ i ur ne u~eae : ..Q
Daîe. Time. Dl=.e =nne DX.COs, Os, R. Q pro Temp.
pr per gm. mg. duced. of dog.
5/9/I3 9-45-I0.45 8.62 9.22 0.68 2I.73 38.6
Io.45-II-45 9.97 I0.55 0.69 27.I2 38.6
8.50o-I.55 I.74 0.56 3.O8
I2.35- I.05 I50 C.C. exts. of pancreas and duodenum from 2 normal dogs
injected intravenously. 20 gms. glucose given per os.
21.55- 2.05 I.o7 0.39 2.70
I.55- 2.55 I3.60 I4.I3 0.70 39.6
2.55- 3.55 I I.84 II.78 0.73
3.55- 4.55 IO.I6 Io0.7I o.69 39.9
_ I.05- 5.05 0.45
Already in the first hour's urine, including the period of
injection, a marked decline in the sugar elimination is seen, showing
that the typical effect on the excretion of sugar would have been
produced, if glucose had not been fed. With 20 grams of glucose
available, however, none, or an extremely small quantity at the
most, was burned. The increase in respiratory metabolism the
first two hours was due to restlessness of the dog.
Other experiments after injection of pancreatic extract alone
and after injection of normal dog's blood likewise showed no
effect on the respiratory quotient.
Incidentally it has been found in the single experiment in the
respiration calorimeter that the heat production in the depan-
creatized dog was from 30 to 50 per cent. higher than the normal
on the same dog determined one month earlier. This confirms
the observations of Benedict and Joslin in severe cases of human
'Benedict and Joslin, Carnegie Institution of Washington Publication No. 276.