I72 SCIENTIFIC PROCEEDINGS (54).
on the days immediately following. When the urine was collected
in short periods after injection, a marked fall in the sugar output
was witnessed lasting from four to ten hours but this was followed
by a compensating rise which, in some instances, augmented the
total for the twenty-four hour period, in others raised it only to
the previous level.
Much greater effects were obtained with a double extract of
dog's pancreas and duodenal mucosa. The following experiment
(No. II) is typical. The effect, however, cannot be ascribed to
the organic extract from either the pancreas or the duodenum for
the same Ringer's solution in which the tissues were extracted
when made alkaline to about the same extent with Na2CO3 gave
an identical effect.
DOG "Q." OPERATED APRIL I7.
Vol. Glu- Nitro- Blod
Date. Time. urine, cose, gen, D: N. Glucose per Nitrogen sugar
c.c. gmn. gmn. hour. per hour. p cent.
4/21/I3 I2.15- 2.15 30 2.4I 0.95 2.52 1.20 0.47 o.128
2.I5- 4.I5 50 2.40 I.o9 2.20 1.20 0.54
5.co- 5.30 I50 c.c. of pancreas and duodenum from 2 normal dogs inj.
4.1I5- 6.1I5 30 I.30 o.67 I.93 0.65 o.35
6.I5- 7I.15 25 0.28 0.33 0.87 0.28 0.33
7.I5- 8.I5 26 o.41 0.45 0.89 o.4I 0.45 o.I48
8.15- 9I.15 26 0.59 0.48 I.21 0.59 0.48
9.15-Io.15 22 0.5I 0.39 I.28 0.51 0.39
4/22/I3 IO.15- 6.00oo 18.66 6.99 2.68 0.93 0.35
4/24/I3 2.I-4.I9 22 I.65 1 0.541 3.08 0.82 0.27
4.26-5.15 Iso c.c. Ringer's Sol. +I-%NaîCOs injected intravenously
4.I9-6.I9 60 I.65 0.64 2.55 0.82 0.32
6.19-8.19 24 0.46 0.52 0.88 0.23 0.26
4/24-25 8.I9-I.I9 90 2.4I 0.59 I.62 0.48 0.29
The similarity in these two experiments on the same dog
indicates that it is not a hormone which is responsible for the
reduction in the sugar, and the increase in the percentage of sugar
in the blood indicates that the reduced sugar elimination is in
reality due to a change in the permeability of the kidney, as
Wohlgemuth2 has found it after ligation of the pancreatic ducts.
That there is no effect on the combustion of sugar attending
Wohlgemuth, Bcrl. klin. Woch., February 24, I9I3, p. 339.