INFLUENCE OF PANCREATIC AND DUODENAL EXTRACTS. I7I
and cabbage succumbed to a dose of 0.4 gm. of the salt per kilo
when given by subcutaneous injection. Suppression of urine was
usually observed on the first day and death occurred in six to
seven days. In starvation, slightly smaller doses were fatal to
some rabbits. The resistance was increased considerably when
the diet was changed to carrots. Such animals stood I.O gm. per
kilo by subcutaneous injection, while 1.2-I.5 gm. per kilo were
toxic. A moderate degree of tolerance for tartrates was in-
duced in animals which were fed oats and cabbage. By grad-
ually increasing the dose, a large proportion (6 out of 9) of rabbits
survived 0.8 gm. per kilo which is twice the fatal dose. Rabbits
which were receiving carrots did not acquire tolerance for tar-
trates. Sodium tartrate was much less toxic when given by
mouth. 5 gm. per kilo was found to be the minimum fatal dose.
EXPERIMENTS ON CATS.
Amounts which have been found to be fatal for rabbits did
not produce any symptoms in cats. Subcutaneous injection of
one gm. per kilo produced a slight diarrhea in some individuals,
and had no effect whatever in others. I- gm. per kilo proved
fatal to one cat but was without action in another. Out of four
cats which received 2 gm. per kilo three died, one survived. When
sodium tartrate was given by mouth vomiting frequently occurred.
In one case, however, when ten gm. per kilo were fed diarrhea was
the only effect observed.
The influence of pancreatic and duodenal extracts on the gly-
cosuria and the respiratory metabolism of depancreatized dogs.
By J. R. MURLIN and B. KRAMER.
[From the Physiological Laboratory of Cornell University Medical
College, New York City.]
Several dogs completely depancreatized by Hedon's method
and eliminating glucose and nitrogen in Minkowski's ratio were
treated by intravenous injection of pancreatic extract prepared
by Knowlton and Starling's method.' The urines collected in
twenty-four hour periods exhibited an increase in the D: N ratio
Knowlton and Starling, Journ. of Physiol., I912, XLV. p. I46.