212 Morphology and Physiology of Areas of Langerhans
in the fresh pancreas of the new-born infant. No connective tissue can be made
out in the pancreas of the four-year-old child with the ordinary stains, but
with Mallory's stain a delicate capsule surrounding the area and delicate
sheaths around the blood sinusoids can be made out.
In the pancreas of the new-born infant, nearly all the areas observed were
found in the interlobular connective tissue and surrounded by it, but no connec-
tive tissue could be made
out within the areas. In
Fig. 8 are reproduced sec-
tions of two insulae from
91r~ ~ the pancreas of the four-
year-old child. The cells
1 1 _ i _ , are somewhat smaller, the
nuclei appearing smaller
and more crowded than in
the islands of the adult pan-
rw ~~ (^~ ~~ t^~~~~ 9creas. This is still more the
-- ' - i -'case in the areas of the
younger child. In Fig. 8, B
-- - ~ z ashows an area which has ir-
. D regular projections into the
--*~~ p~ ~acinal tissue, as if it had
been somewhat broken up
.... --" i by the ingrowth of acini.
It is evidently not so near
the center of the island as
A, which represents a very
typical section. In the
adult, at least inmostof the
J'X~~~ < o 1: islands seen by me, there
is more connective tissue,
forming rather definite tra-
Ibecule, which divide the
island into smaller compart-
ments containing the cells;
'2 tbhis recalls the description
given by Harris and Gow,
who, because of this tend-
ency, speak of the huîman
areas of Langerhans as
compound. Sometimes the
connective tissue forms,
Fig. 9, A and B.-Central sections through two 'with the larger blood-ves-
sels, one or many larger tra-
areas of Langerhans of the human pancreas. X 2 oo. sels, e or many larger tra-
beculæe passing through
the center, other septa passing to the sides, much as described and figured by
Flint. Such an area is shown in Fig. 9, A, showing the central strand cut longi-
tudinally, while in B, it appears to be cut transversely, giving the radiating