206 Morphology and Physiology of Areas of Langerhans
I. o.i2 x 0.22 x 0.09 mm......... .......... 0024 c. mm.
2. 0.15 x o0.23 x O.I5 mm................... 0052 c. mm.
3. o.o8 x 0.23 x O.I8 mm....................00o33 c. mm.
4. o. I2 x o. iS x o.IO mm............... o0.002I C. mm.
5. o.I6 x 0.20 x O.I5 mm..................0.0048 c. mm.
6. 0.o 13 x o. I6 x o.18 mm ......... ........... o0037 c. mm.
7. o I5 x o.23 x o.o8 mm ................o.00oo28 c. mm.
8. o. Io x 0. i x o.095 mm.................. o .OOII C. mm.
9. o.I4 x o.I8 x 0.255mm............ .....0.0064 c. mm.
Io. o.i5 x 0.i5 x o.lo mm. .......... 0.......0o.oo23 c. mm.
A comparison of these measurements shows a considerable difference ill the
actual size of the areas, since Number g is nearly six times as large as Number 8.
As may be seen from the measurements, as well as from Plate XII, Figs. 2 and 3,
which reproduce two wax reconstructions of fairly typical islands from the
pancreas of a rabbit, the islands are nearly always considerably longer in one
dimension than in the other two. They are not, however, at all regularly oval.
since there are numerous projections which run out between the pancreatic
acini. The cells are of about the same types as described for the guinea-pig
and rat, but in the sections observed by me there was an unusually large number
of the large distinctly contoured eosino-
phile cells, with large, excentric, deeply
staining nuclei. Such cells are more nume-
rous near the periphery of the area. These
often seem to merge into the acinal cells
-,,~__mlso gradually that no line of demarcation
can be made out. In some places the lines
of nuclei in the bands of cells pass out reg-
ularly into the cells of a longitudinally
cut tubule which shows the typical basal
position of the nuclei and the nuclear stain
8[tés~~~ ^ 11of the basal protoplasm, eosinophile gran-
ules being present in the central portion
of the protoplasm. The same or similar
appearances are not rarely seen in all forms
in which the capsule is very thin and the
~~--D i ~relation to the acini very close. I have,
however, regarded the two structures as
separate unless, as frequently happens in
the rabbit, the connection can be clearly
traced through several sections of the se-
Fig. 5.-Section through the ries. This has been done in numerous in-
center of an area of Langerhans stances in the rabbit and the connection
from pancreas of the rabbit; p, may be seen in the models represented in
connection with pancreatic tu- Plate XII, Figs. 2 and 3, and also in the
bule. X 200. section shown in Fig. 5. This appearance
can best be explained by the fact shown
by Pearce and others that the areas develop
fromthe same epithelial anlage as do the pancreatic tubules, and it may easily be