Subtitle: 'VI. The Influence of Pancreatic Extracts Without the Aid of Alkali upon the Metabolism of the Depancreatized Animal.' Following title: 'From the Physiological Laboratory of Cornell University Medical College, New York City.' This article is the fourth in a series published by John R. Murlin et al. on pancreatic diabetes in the dog. The first three articles were published in the Journal of Biological Chemistry, vol. 27 (1916).