Following title: 'From the Physiological Laboratory, Cornell University Medical College, New York City. Received for publication, September 29, 1919.' The articles is in three sections: I. The influence of alkali and acid upon the glycosuria and hyperglycemia. II. Is the glucose retained when sodium carbonate is administered to depancreatized dogs deposited as glycogen? III. The influence of alkali on the repiratory metabolism after total and partial pancreatectomy.