256 Aqueous Extracts of Pancreas. I
extracts of cat's pancreas were made and prepared for adminis.
tration in several different ways. Among these, two made in
acid media proved more successful when applied to the depan.
creatized cat than the others and may be presented. Because
of the necessity ultimately to prove the combustion of sugar,
whatever be the effect on hyperglycemia or glycosuria, we deter-
mined to direct our efforts to this objeotive at once by studying
TABLE I.
Influence of Extract of Cat's Pancreas on Respiratory Metabolitsm of Cat.
Cat 1.
Inspired air. Expired air.
Date and time. Treatment. ANal .i R.Q.
No. RQ
CO, Os CO: O,
191I per cent wr cent pe ent pvr cnt
Dec. 29 168 0.03 20.92
169 0.03 20.93
"1 30
4.00 p.m. 173 0.26 20.62 0.697
4.15 " 174 0.25 20.63 0.67
Alcohol check. 175 0.219 20.665 0.666
Dec. 31
2.30 p.m. 184 0.25 20.625 0.697
3.00 " 184 0.231 20.68 0.717
6.30 " Given one-fourth of total extract
of cat's pancreas. i.v.*
7.05 " 188 0.299 20.6I8 0.825
8.00 " 191 0.200 20.72 0 773
8.30 " 192 0.190 20.735 0.763
19ts
Jan. 2 Cat died, no pancreatic tissue.
* In this and the following tables i.v. represents intravenous administra-
tion; s.c., subcutaneous; i.m., intramuscular; and i.p., intraperitoneal.
effects upon the respiratory quotient first and not to pay any
regard to preparations which would not influence the quotient.
The first ofthese experiments performed on Cat 1 is shown in Table I.
The cat had been depancreatised several days before, and both on Dec. 30
and 31 gave good diabetic respiratory quotients. An alcohol check upon the
efficiency of the apparatus (Paper I on perfusates (23)) obtained on
Dec. 30 likewise is included in the table and shows an unusually perfect