tolneal injections of an extract of the anterlior
lobe of the pituitary glanld.
Abel, Rouiller and Geiling22 have obtaiiied
the hormone of the posterior lobe of the piti-
itary gland in a much more highly purified
form than has heretofore been accomplished.
Their preparation is of such a high degree of
purity that it produces pronounced contrac-
tions in the virgin uterus of the guinea pig in
dilutions greater than 1:18,750,000,000. This
is perhaps one of the most striking illustrations
yet described of the enormnous potency of cer-
tain physiological principles.
Ovary.--An ovarian hormone contained in
the liquor follieuli has been clearly demon-
strated by the work of Allen and Doisy23 dur-
ing the past year. It is the hormone of oes-
trus. They have found that typical oestrus
changes can be induced in spayed rats by the
injection of extracts prepared from the liquor
folliculi of hog ovaries.
Adrenal Cortex. -Marine24 has been able to
demonstrate a definite increase in the meta-
bolic rate of rabhits in which cortical tissue of
the adrenals has been largely removed. This
vould point to an interrelation between the
thyroid gland and the cortical tissue of the
adrenal. The investigations being conducted
upon this problem hy Marine and his associates
would seem- to hold considerable promise.
(]1) MERING AND MINKOWSKI, Arch. f. exp. Path. u.
Pharm., 1889, xxvi, 371. (2) BANTING AND BEST, J.
Lab. and Clin. Med., 1922, vii, 251 and 664. (3)
SCHAFFER, J. Biol. Chem., 1921, xlvii, 449, xlix, 143.
(4) BANTING, BEST, COLLIP, MACILEOD AND NOBLE,
Amer. J. Physiol., 1922, lxii, 559. Trans. Boy. Soc. Can.,
1922, xvi, Series 3, Section 5. (5) BANTING, BEST,
COLLIP, HEPBURN AND MACLEOD, Trans. Roy. Soc. Can.,
1922, xvi, Series 3, Section 5. (6) BANTING, BEST, COL-
LIP, CAMIPBELL AND FLETCHER, Can. Med. Assoc. J., 1922,
xii, 141. (7) MACLEOD, Physiol. Reviews, 1924, iv, 21. (8)
BURN, J. Physiol., 1923, lvii, 318. (9) OLMSTED AND
LOGAN, Amer. J. Physiol., 1923, lxvi, 437. (10) DALE,
LANCET, 1923, May. (11) BRIGGS, KOECHIG, DOISY AND
WEBER, J. Biol. Chem., 1924, lvii, 721. (12) WINTER
AND SMIITH, Brit. Med. Jeur., 1923, Jan., April and