Intarvin.-Experimental work has shown
that a fatty acid which has an odd number of
carbon atoms in the molecule, does not pass
through the ketone stage during its katabolism.
An odd numnber carbon atom fatty acid is there-
fore non-ketogenic. Max Kahn19 has demon-
strated that intarvin, a synthetic odd carbon
atom fat can be assimilated by the diabetic
subject without the production of ketones.
Sevringhaus20 has definitely established that
odd carbon atom fats such as margaric acid
esters or intarvin are neither ketogenic nor
antiketogenic. Such substances may, however,
be used in the diabetic dietary to supply calor-
ies but will have no effect on ketonuria unless
the natural fat in the diet is reduced or re-
placed by a synthetic odd carbon atom fat
such as intarvin.
Treatment of diabetic acidosis by the use of
intarvin is therefore quite different from treat-
ment with insulin. Ketosis is prevented in the
former method by the use of a synthetic fat
food which will not give rise to ketone bodies
in the process of its metabolism.
Intensive experimental investigation of the
endocrines other than the pancreas is being
carried out in many laboratories and along cer-
tain lines distinct progress is being made. A
few outstanding features of some recent work
may be of interest at this time.
Pituitary Gland.--Some very suggestive work
which may ultimately lead to the isolation in
stable form of certain pituitary hormones has
been published of late by Smith and Smith."'
They have found thattadpoles which have
been hypophysectomized manifest four abnor-
malities, viz., diminished rate of growth, dimin-
ished pigmentation, faulty development of
thyroid and inter-renal bodies. and enlargement
of the fat organ. They have been able to
correct all these abnormalities in hypophy-
sectomized tadpoles by continued intraperi-