134 THE ROYAL SOCIETY OF CANADA
In two other well-fed rabbits kept under urethane for periods
of 5 to 7 hours the following final values were found:
1. Blood sugar rose from 0.114 per cent. to 0.330 and after 7 hours
the liver glycogen was 2.80 per cent.
2. Blood sugar rose from 0.127 to 0.310 and after 5 hours the liver
glycogen was 0.69 per cent.
When insulin was also given (Feb. 28th) the glycogen to start
was 5.86 per cent. and the blood sugar fell as a result of 24 u. insulin
to 0.103 per cent. The glycogen at the end was 5.76 per cent.
So far as these observations go they show that when sufficient
insulin is given to prevent the development of hyperglycaemia as a
result of urethane the glycogen of the liver is conserved.
Further work of a similar character but using ether as the
anaesthetic is in progress.
Department of Physiology,
University of Toronto.