BEST 627
study of the effect of large doses of insulin on dogs. As this
work is by no means completed, I will present our results only
very briefly. In Table III the effects of varying doses of insulin
upon a normal dog are shown. This animal had approsimately
one week's rest between each two experiments. The animal was
on a constant diet for several wseeks before and cduring the experi-
ments. The insulin was injected at the same time of day in each
experiment. A study of the chart reveals the irregular nature
TABLE III
LLJ VARYINC DOSES OF INSULIN ON A NORMAL DOG
Cn QI
TIME IN HOURD
of thle resnlts. I n SOnIl(' bult liot iii all experijîneuts, uc lOiVi
lloteil at definite incre ase usl tlhe inlsnlml conltenlt ut thew urinle afte r
large inltravenous doses of îiisululi. 1l olne exl)erIilneiilt aul anlimlal
xvals killedl some foulr Isoulrs afteî a veryr lalrge} dose . Va~rionls
tissues w-ere extraetedl cand tIse e.xtraet testedc onl ral)lsits. At
definite incerecase in tlue inlsulinl contesît of tise kidnev( w-as found,(
but other tissues containe(l olv normal amounts. Iloweveit i
secins probable that inlsulinl mnacy lie storedl ils thle bodx- once't anl
canimlal mlay app)arenltly eomîîleely+l recover ftrom thle elfeets luit
cat a. sssbse(îuent tîmle exliîl)t lix-lsoglv-eenliia andl( covulsxionls. Au1
awnimal occasionally exslinhîts tinis teînplorary! reeover- when(1 dexe-
trose is not adnnnilistued W(( \ej hlope tl-act fîuitltse onu-k xxiii
LL-J
a3o:
©- o
£J
TIHE INHOR
of' thec results. IIn somei. buit not in anll experimenerts, w~e hayl(,
notedl ai definite increas~e ill tlie inisulin content of the uirinie afteri
large initravenous doses of insuiliil. TIn onec exI,eri nu'nt al~ animiral
was killed some fourï hiours aft{'r· a very lar,rge dos{,Vriu
tissues w-ere extr·actedi and thc exstract tested~ oni rahM.,ts. A
definite increase in thie inisulini conitenit of thie kidney w nas f{mndic,
but other tissues contained~t only` niormial amiouints. I[owever,i · it
seems probable that insulini miay- be stored~ ini thie bodycl sin{-et ani
arinimal miay ap,l)arently compile·tely- recover from thec effcts huit
at a subseqluent timec exib~it hy!~)ogly- cemri a andl conivulsionis. A
animal occasionally exhrib)its thiis tempiIorary r·ecovery! whenC1 dexS-
tr·ose is not adminisiiitc,'rdc~. Wc hiol'te that furitherli w\orkI w\ill