626 RECENT WORK ON INSULIN
This diabetic animal was given large quantities of dextrose and
beetroot extract. The liver at autopsy contained over 9 per cent
glycogen. No pancreatic tissue was found. As our knowledge
of the properties of this purified plant extract increases the sim-
ilarity between it and pancreatic insulin becomes more marked.
The yields of this active material from plants are very small
TABLE II
BEET ROOT EXTRACT RESULTS
" '(- 50 UNITS OF INSULIN
o4- IOC.C'S BEET ROOT EXT
oo\ - IOC.C.S BEET ROOT EXT
w
L,.
w
o.-_
0.1 1 3 5 b 7
(- 0.0/
0.1
O
TIME IN HOURS
anld the raw mnaterial is processed with much greater difficulty
thaln is pancreas. The peculiar animal transfer phenomenon
lnoted by Collip (35) remains as yet unexplained.
TIIE lI:FFECTS OF LARGE DOSFS OF IN'SULIN ON DOGS
It hlas e(oiirte appareint to many of tlhose who have used
rablbits extenisively in testing insulin that a large dose does not
invariably produirce a greater effect upon ani animal than a much
smiialler amouniit. This effect appears to be independent of the
glycogen store of the animal at tlhe time of the experiment. The·
w·ork of F`. N. Allen on dogs is interesting in this connection and
h'as bceen refrared to previouisly. Smith and I are engaged in a