ELLIOTT P. JOSLIN, HORACE GRAY AND HOWARD F. ROOT 655
obviously such small dosage as to make inclusion in this table
unfair. The five deaths which occurred in the entire group are
discussed in another place, though it may be said here that in no
instance, save that already mentioned of Thomas D., was insulin
related to the death of the patient.
In Table 1 are recorded the age at onset of the diabetes and at
the beginning of treatment, the number of days during which
insulin has been administered, the total number of units of insulin
given, and the analysrs of sugar in the urine and blood at the
beginning of treatment and at the last observation. The data
upon the weight are recorded in detail.
Duration of Treatment and Number of Units Administered
Miss M., Case No. 1542, is the longest under treatment, having
been observed for 165 days, though upon 7 days no insulin was
administered subcutaneously. During this period she has
received 2,555 units. This number of units is exceeded only by
Case No. 2801. Though the latter, a girl of 15 years with adol-
escent goitre, began treatment a little later, she has received
3,246 units and is one of the patients receiving over 30 units daily.
Case No. 2256 comes next in number of units taken, and is des-
tined to surpass the other two, because in a shorter period she has
been given 2,464 units.
The table also furnishes information to some extent on the
number of units taken in successive months. Fourteen cases
have been treated for 30 days or less, and these cases have aver-
aged 11 units per day. Sixteen cases have been treated between
31 and 60 days, and these cases have averaged 12 units per day.
Thirteen cases have been treated between 61 and 90 days, and
have averaged 11 units per day. Seven cases have been treated
between 121 and 150 days, and have averaged 11 units per day.
Finally, three cases have been treated for 151 or more days, and
have averaged 11 units per day. At the present writing there are
eleven patients who are not taking over 10 units, thirty-seven
patients who are taking between 11 and 20 units, and two patients
who are taking between 21 and 30 units, and three patients who
are taking 31 or more units. Encouragement, therefore, is justi-
fiable in the belief that from month to month the dosage of insulin
need not be increased.