Item is a Walker's Re-form/fill Patent Duplicate Book with perforated leaves and originally containing a total of 200 pages. These pages consisted of 100 original pages and 100 duplicate pages numbered 1 to 100. The notebook contains notes made in F. G. Bantings, C. H. Bests, and E. C. Nobles hands. Glued to the first page is a note, made on lined paper, in ink, in Bantings hand. The note lists questions about the experiments including Is it trypsin or other ingredients of pan juice that destroys Isletin. The notebook begins with a series of calculations made in pencil, in Nobles hand. These notes are undated and appear to record calculations for experiments done on cats. Notes recording experiments on dogs in Banting and Bests hands begin on page 51. These notes are dated Aug. 11 to Sept. 16, 1921 and are carbon copies with corrections and additions made in pencil. The notebooks records experiments done on Dog 409, Dog 92, Dog 394, Dog 9 and Dog 5.