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I hope to be in Toronto at the end of this week or early next week, and shall look forward to having an opportunity of talking over various questions with you. From some preliminary results with dogs under an anaesthetic or hypnotic I am inclined to think that this may afford as
good a means as any of standardizing Insulin. I have had some very interesting letters from Dale in one of which he tells me that the discrepancy between his results and those of Krogh on mice is 6 to 1. This does not sound very hopeful and indicates the difficulty of securing uniform results using methods of physiological assay.
The truth is that no accurate results can be obtained on animals other than on the basis of statistical data or large scale averages. We have lately had the opportunity to run a good many hundred tests by MacLeod's method and are convinced that we should not be willing to draw final conclusions regarding the strength of a lot on less than one hundred rabbits using this method.
I was certainly delighted to hear of the reception you had in London and in other places. You certainly are receiving the recognition to which you are entitled. When I look back on your visit to me here last Autumn and your somewhat pessimistic attitude at that time I realize that very considerable strides have been made in the past year. We were all of us greatly mystified at the announcements that appeared in the public press regarding the very heavy insurance on your life and I shall certainly want to hear the explanation of this story when I see you.

Yours sincerely,
G. H. A. Clowes
Director of Research.

GHAC:FC
(signed and despatched in Dr. Clowes' absence.)