May 18th, 1923

Dr. G. H. A. Clowes
Eli Lilly & Company
Indianapolis, Ind.

Dear Dr. Clowes,

Would you please send 500 units of Insulin to Prof. Sutherland Simpson, Cornell University Medical College, Ithaca, N.Y. Simpson writes me that they have obtained some interesting results on the antagonism between thyroxin and Insulin and they would like to repeat this work to make certain of their findings. The samples they had before were form lot No. 68466-725710.

Will you please also send us 2,000 units of Insulin for the purpose of testing its assay on diabetic dogs. As I told you we are obtaining some results in the connection that are decidedly encouraging but the present part of ht problem demands that we make a considerable number of observations with exactly the same preparation of Insulin at different carbohydrate balances. The lot which you sent us before was numbered 789 and if you could send us this same batch it will, of course, simplify matters considerably. We are not prepared to say as yet whether this methods of assay is to be of practical value but the results indicate that this possibility should be intensively investigated.

I had a telegram from Puckner from which it appears that the A. M.A. are prepared to accept Insulin and Insulin, Lilly for "New and Nonofficial Remedies." Have you any idea when they propose to publish this?

Referring to the list of the suggested Insulin Committee in Holland will you please add the name of Prof. H. J. Hamburger, Institute of Physiology, University of Groningen, Groningen, Holland.

With regards, I am
Yours very truly,

Secretary, insulin Committee
University of Toronto

JJRM/MG
Encl.

P.S. Since dictating this letter I have received Mr. Eli Lilly's letter and have forwarded the same to Mr. Russell who is taking charge of the final revision of the agreement. I will telegraph whenever we are ready to have Mr. Lilly come here.