The Lilly Research Laboratories
Eli Lilly and company
Indianapolis, ind., USA

Director
GHA Clowes

Septerber 27, 1922.

Dr. J. J. R. MacLeod,
Department of Physiology,
University of Toronto
Toronto, Canada

Dear Dr. MacLeod:-

I received your letter of September 23rd and have forwarded to Dr. Walters the addresses of the Canadian physicians you mentioned.

I have no doubt that we shall be able to supply these physicians in the near future as our output will be increased when the big plant starts running properly.

I hope to get the problem of protein in Iletin straightened out in the near future. I think that you will agree with me after receiving the specimens forwarded by Dr. Walters that the problem of concentration is no longer presenting any difficulties.

On account of the enormous demand for Iletin which is springing up all over the United States, I think we shall have to arrange to sell it on a cost basis very soon, but will discuss this matter in detail with you in Toronto.

As regards to the U. AS. Patent. As I explained to you in my previous letters, this patent is taken out by Eli Lilly and Company to safeguard themselves and protect in some measure the large amount of developmental work which they have carried out at very great cost in the course of the last two or three months. This patent application is a purely technical matter but has considerable importance from the standpoint of an industrial organization. I agree with you in disapproving of its wording in certain sections, as I stated in my last letter, but matters of this type are taken care of by our technical and patent experts and they have presumably followed an approved course in the matter.

Unfortunately I forwarded my copy to Best and have none at my disposal at the moment, but I am convinced that I could reword the patent application to